2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-103005R
    Ramelteon metabolite M-II (Standard)
    Amlodipine (maleate) (Standard) is the analytical standard of Amlodipine (maleate). This product is intended for research and analytical applications. Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer.
    Ramelteon metabolite M-II (Standard)
  • HY-78841S
    (2S,4S)-Sacubitril-d4
    (2S,4S)-Sacubitril-d4 is deuterium labeled (2S,4S)-Sacubitril. (2S,4S)-Sacubitril is the impurity of Sacubitril. Sacubitril is a potent NEP inhibitor that can be used for the research of heart failure.
    (2S,4S)-Sacubitril-d<sub>4</sub>
  • HY-131314
    Ibuprofen carboxylic acid
    Ibuprofen carboxylic acid is the metabolite of Ibuprofen (HY-78131), that has high concentrations in wastewater and water environments, and disappears fast during biodegradation, compared to the other ibuprofen metabolite.
    Ibuprofen carboxylic acid
  • HY-W344074
    Cytarabine 5’-monophosphate
    Cytarabine 5′-monophosphate is a metabolite of the nucleoside analog Cytarabine (HY-13605), catalyzed by deoxycytidine kinase. Cytarabine 5′-monophosphate is incorporated into DNA by DNA polymerase α, which reduces the rate of DNA synthesis. At a concentration of 15 mM, Cytarabine 5′-monophosphate inhibits nuclear and mitochondrial DNA replication in Saccharomyces cerevisiae (S. cerevisiae). Additionally, Cytarabine 5′-monophosphate (3.5-75.1 mg/kg) improves survival in leukemia mice (L1210 mice). Cytarabine 5′-monophosphate can be used in cancer research.
    Cytarabine 5’-monophosphate
  • HY-133672
    (Rac)-Mono(3,5,5-trimethylhexyl) phthalate
    (Rac)-Mono(3,5,5-trimethylhexyl) phthalate is a important metabolite of commonly used phthalate plasticizers. (Rac)-Mono(3,5,5-trimethylhexyl) phthalate has immuno-suppressive effect.
    (Rac)-Mono(3,5,5-trimethylhexyl) phthalate
  • HY-W775325
    7-Hydroxycannabidiol
    7-Hydroxycannabidiol (7-OH-CBD) is the metabolite of cannabidiol, which could be found in human serum and saliva.
    7-Hydroxycannabidiol
  • HY-128459R
    N-Demethylerythromycin A (Standard)
    N-Demethylerythromycin A (Standard) is the analytical standard of N-Demethylerythromycin A. This product is intended for research and analytical applications. N-Demethylerythromycin A is a metabolite of Erythromycin A. Erythromycin A is an antibiotic.
    N-Demethylerythromycin A (Standard)
  • HY-116787R
    5-Hydroxythiabendazole (Standard)
    5-Hydroxythiabendazole (Standard) is the analytical standard of 5-Hydroxythiabendazole. This product is intended for research and analytical applications. 5-Hydroxythiabendazole (5-OHTBZ) is a biomarker of Thiabendazole (HY-B0263) exposure.
    5-Hydroxythiabendazole (Standard)
  • HY-13256AS
    Desmethyl Erlotinib-d4
    Desmethyl Erlotinib-d4 is the deuterium labeled Desmethyl Erlotinib. Desmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor[1][2]. Desmethyl Erlotinib-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Desmethyl Erlotinib-d<sub>4</sub>
  • HY-Z7429
    3-Hydroxy-4-methyl-2(5H)-thiophenone
    3-Hydroxy-4-methyl-2(5H)-thiophenone (compound 18) is a pyrazine derivative and the major acidic degradation product of Cephalexin (HY-B0200).
    3-Hydroxy-4-methyl-2(5H)-thiophenone
  • HY-172055
    PB-22 N-(5-Hydroxypentyl)-3-carboxyindole metabolite
    PB-22 N-(5-Hydroxypentyl)-3-carboxyindole metabolite is a metabolite of PB-22. PB-22 is a cannabinoid.
    PB-22 N-(5-Hydroxypentyl)-3-carboxyindole metabolite
  • HY-145482R
    W36017 (Standard)
    8-Hydroxyquinoline (hemisulfate) (Standard) is the analytical standard of 8-Hydroxyquinoline (hemisulfate). This product is intended for research and analytical applications. 8-Hydroxyquinoline hemisulfate (8-Quinolinol hemisulfate) is a monoprotic bidentate chelating agent, exhibits antiseptic, disinfectant, and pesticide properties, functioning as a transcription inhibitor.
    W36017 (Standard)
  • HY-139232
    17(R)-Resolvin D3
    17(R)-Resolvin D3 is a metabolite of docosahexaenoic acid (DHA). 17(R)-Resolvin D3 has anti-inflammatory activity.
    17(R)-Resolvin D3
  • HY-B2124R
    10,11-Dihydrocarbamazepine (Standard)
    10,11-Dihydrocarbamazepine (Standard) is the analytical standard of 10,11-Dihydrocarbamazepine. This product is intended for research and analytical applications. 10,11-Dihydrocarbamazepine is the active metabolite of Oxcarbazepine. 10,11-Dihydrocarbamazepine also is an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-Dihydrocarbamazepine with probable Anticonvulsant efficacy.
    10,11-Dihydrocarbamazepine (Standard)
  • HY-W740165
    Desmethyl Levofloxacin hydrochloride
    Desmethyl Levofloxacin hydrochloride is an antibacterial agent with broad-spectrum antibacterial activity against a variety of pathogens. Desmethyl Levofloxacin hydrochloride effectively fights bacterial infections by inhibiting bacterial DNA synthesis. Studies on Desmethyl Levofloxacin hydrochloride have shown that it has potential in inhibiting respiratory infections.
    Desmethyl Levofloxacin hydrochloride
  • HY-W007077
    (2-Amino-5-bromophenyl)(pyridin-2-yl)methanone
    		Control
    (2-Amino-5-bromophenyl)(pyridin-2-yl)methanone is a precursor in the synthesis of benzodiazepines and is also a hydrolysis product of Clonazepam.
    (2-Amino-5-bromophenyl)(pyridin-2-yl)methanone
  • HY-Z6663
    Salbutamol methyl ether
    Salbutamol methyl ether is a derivative of Salbutamol (HY-B1037) used as an immunohapten to obtain antibodies.
    Salbutamol methyl ether
  • HY-145453R
    Propacetamol (Standard)
    		Control
    Propacetamol (Standard) is the analytical standard of Propacetamol. This product is intended for research and analytical applications. Propacetamol is an analgesic agent. Propacetamol also is a precursor form of paracetamol. Propacetamol can be used in postoperative pain, acute trauma and gastrointestinal disorders.
    Propacetamol (Standard)
  • HY-W728879
    5-Aminoisotonitazene
    5-Aminoisotonitazene is a urinary metabolite of the analgesic, synthetic opioid agent isotonitazene.
    5-Aminoisotonitazene
  • HY-N8500
    Aristolochic acid Ia
    Aristolochic acid Ia is an oxidative metabolite of aristolochic acid I, which can be used to study the detoxification pathway of aristolochic acid metabolism.
    Aristolochic acid Ia
Cat. No. Product Name / Synonyms Application Reactivity